Synthesis Technology
Oxidation reaction
TAOKA owns facilities to produce peroxides, and has a substantial track record in their handling. We also own a peracetic acid manufacturing technique.
· Reaction for C-C unsaturated bond
· Reaction for carbonyl (Baeyer-Villiger Oxidation)
Reduction reaction
A reduction reaction is an extremely important reaction in synthesizing various organic compounds. TAOKA has a substantial track record in industrialization, including the conversion of the nitro group into the amino group by a hydrogenation reaction, and a reaction to reduce the carbonyl group using borohydrides.
· Hydrogenation reaction
· Borohydride reduction
Halogenation reaction
TAOKA has a substantial track record in successfully achieving the industrialization of numerous processes that include halogenation reactions using thionyl chloride, sulfuryl chloride, chlorine, etc. For bromine, in particular, we own a tank at the company.
· Bromination reaction
· Chlorination reaction
Grignard reaction
The reactions to form carbon-carbon bonds are extremely important reactions in the synthesis of various different chemicals. The Grignard reaction is one of the most typical of such reactions. TAOKA has the facilities and know-how to conduct a Grignard reaction on a scale of 10,000L, and has successfully industrialized various processes.
Dehydration condensation reaction
TAOKA implements the development and production of various bisphenol derivatives to meet the needs for high performance and high function substances that are growing in recent years, and has a substantial track record in conducting reactions between phenol derivatives and carbonyl compounds.
Reaction using NaH (water-sensitive reaction)
We conduct reactions using NaH on a scale of 10,000L.
Lithiation reaction using nBuLi
TAOKA owns the facilities and techniques to safely handle nBuLi, and uses it on an industrial scale.
Indole derivatives
Indole derivatives play important roles as intermediates for various compounds, mainly for pharmaceutical applications. TAOKA develops indole derivatives with various substituents, and have successfully developed many derivatives. We also have proprietary techniques for introducing normally difficult to introduce substituents or those whose orientation is difficult to control.
Other manufacturing processes and derivatives TAOKA has experience in (examples)
- · Pyrazole ring synthesis
- · Friedel-Crafts reaction
- · Nitration reaction
- · Diazotization reaction